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Jean Stéphane JOLY

Comparative Analysis of Stem cells, Brain Anatomy and Homeostasis

We use fish models, whose brains have the peculiarity to grow continuously during whole animal life. We identified, in the mesencephale, a unique layer of slow-amplifying progenitors (SAP) accessible for long term in vivo imaging. They are adjacent to the optic tectum, which has transitory fast amplifying progenitors (FAP) at its margin. As in the retina, the presence of these SAP and FAP in separate domains speeds their multilevel characterization, and the functional characterization of SAP markers. SAPs share many features with neural stem cells (NSCs). Therefore our comparative study of NSCs should document their diversity and identify essential/core gene-regulatory mechanisms.