|Affiliated doctoral schools|
The central nervous system of vertebrates is a complex assembly of neurons and glial cells, set-up in specific locations and numbers. This largely takes place during early stages of life, but the maintenance of some progenitor cells until adulthood is also crucial as it can be involved in later adaptation, growth or repair events. Our goal is to identify some of the mechanisms involved in controlling neurogenesis and neuronal specification in the embryonic and adult brain, and their influence on behavior. We are using the model system zebrafish (Danio rerio), which offers unprecedented advantages for manipulating gene function both during development and in adulthood, where adult neural stem cells are abundant, and which is also amenable to behavioral assays.